The transcription factor p53: not a repressor, solely an activator.

Cell Cycle · 2014 · PMC4612452 · PMID 25486564

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 10 −27actually significant

This 14-fold increase of gene numbers regulated by HPV E7 in addition to E6 among pocket protein target genes is highly significant ( P < 10 −27 ) and thus substantiates the model that p53 can directly activate its target genes while p53-dependent repression largely occurs via the p53-p21-DREAM/RB pathway.

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