Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle.

The SNP (g.48476925C > T) and the 3-bp indel (g.48476943_48476946insGGC) in the upstream region of ACVR2A produced a highly significant signal ( P = 8.32 × 10 −7 ; Fig. 1b , Table 1 ), whereas the 21-bp indel in the 5′-UTR and the SNP in the 3′-UTR of ACVR2A were not associated with ANAI 4 ( P = 0.028 and P = 0.51, respectively).

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