Additional factors likely to be significant contributors to MTXPG variability include pharmacokinetic variation, physiological and developmental differences in oral absorption, transporter expression and the individual genotypes for MTX multiple metabolic pathways that have been associated with both efficacy and toxicity of MTX [ 48 – 50 ].
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Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study.
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