Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years.

There was a highly significant difference in the distribution of the three polymorphisms at codon 129 over time and incubation period, with each pairwise comparison of genotypes being statistically significant in post hoc analyses [MM mean 30.8 years (95% confidence interval 26.9–32.6), MV mean 23.4 years (9.0–36.7), VV mean 14.3 years (7.7–20.2), ANOVA P < 10 −7 ].

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