borderline significantP < 0.05
However, within the combined FTLD cohort, the presence of any alteration in pain or temperature responsiveness was significantly associated with atrophy of right mid insula (and borderline significant also for right posterior insula) when thresholded at P < 0.05 FWE after correction within the prespecified anatomical region of interest; no significant grey matter associations were identified for pain symptoms or for temperature symptoms separately, at the prescribed threshold.