A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.

MAbs · 2014 · PMC4622569 · PMID 25517308

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at the limit of significanceno p-value reported

Although this difference is rather small and at the limit of significance, it is in agreement with the FcRn SPR analysis data obtained for this sample and suggests that the 20% oxMet428 content may result in improved FcRn affinity and PK properties.

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