Non-antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity.

MAbs · 2015 · PMC4622617 · PMID 25524207

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may be significantno p-value reported

26 This unique structure of IgG 4 may be significant for the FVIII-mimetic activity of our bispecific antibody, and the result suggests that the Ser228Pro mutation may not change the tertiary structure of IgG 4 dramatically.

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