Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.

Whereas centrosomal pT676 staining in cells expressing GFP alone was essentially the same as in untransfected cells (the median value of F pT676 (GFP+)/ F pT676 (GFP–) was close to 1), there was a twofold reduction in centrosomal pT676 in cells expressing GFP-Cetn3 ( Figure 10B ), and the difference between GFP and GFP-Cetn3 was highly significant ( p < 0.0001).

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