While no significant differences were found between SDR alone and MSC-containing SDR in normoxia, pre-incubation for 2 days in hypoxia had a highly significant effect promoting endothelial cell migration into wound edge, suggesting that hypoxic pre-conditioning is essential for promoting blood vessel formation in MSC-containing SDR.
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Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells.
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