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Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells.

Front Cell Dev Biol · 2015 · PMC4626656 · PMID 26579521

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highly significantno p-value reported
While no significant differences were found between SDR alone and MSC-containing SDR in normoxia, pre-incubation for 2 days in hypoxia had a highly significant effect promoting endothelial cell migration into wound edge, suggesting that hypoxic pre-conditioning is essential for promoting blood vessel formation in MSC-containing SDR.

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