miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma.

Oncotarget · 2015 · PMC4627343 · PMID 25980496

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.00001actually significant

There was no significant difference in MM96L when siNF1 was compared with miR-514a, whereas in MM253, particularly at higher drug dosage (10-100nM), the differences between siNF1 and miR-514a, were highly significant ( p < 0.00001) (Figure 5a ), indicating that the mode of BRAFi resistance was different, possibly due to other targeted genes of miR-514a.

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