Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.

J Cell Mol Med · 2015 · PMC4627560 · PMID 26094900

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closest p

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very close to significanceno p-value reported

Both studies showed a tendency towards improvement very close to significance in the primary endpoint of modified motor score (mMS) and found positive effects on the secondary endpoint of the TMS of the UHDRS 34 .

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a slight trendno p-value reported

Mice chronically treated with pridopidine displayed a slight trend towards the preservation of brain weight loss, however, it did not reach any statistically significant difference compared with vehicle-treated mice (Fig.

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