Barely Significant
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Reduced graphene oxide induces transient blood-brain barrier opening: an in vivo study.

J Nanobiotechnology · 2015 · PMC4628296 · PMID 26518450

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highly significantno p-value reported
Another highly significant aspect to consider when studying drug transport and delivery to the brain via nanomaterials relates to the integrity of the BBB throughout treatment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.