Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines.

32 – 34 Only Goldie et al 32 showed a borderline significant advantage for RT for patients with painful arthrosis of the knee joint. 32 Hyperproliferative disorders Morbus Dupuytren—indication, radiation technique and dose The clinical implementation and efficacy of RT in morbus Dupuytren is strongly stage dependent, because the antiproliferative effect is most pronounced in the early nodular stage owing to the biological activity on the mesenchymal target tissues.

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The use of RT led to a highly significant reduction of pain symptoms in both groups; however, the lower dose regimen was equally effective as the higher dose regimen. 10 , 13 , 31 In another randomized clinical trial, the efficacy of two other dose concepts was evaluated in a total of 66 patients who had been treated with either 6.0 Gy with 6 fractions of 1.0 Gy or with 0.6 Gy with 6 fractions of 0.1 Gy.

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