Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors.

Our results indicate that a relatively small drop in membrane cholesterol already results in highly significant attenuation in agonist-evoked G q/11 G-protein-mediated M1 receptor signaling (Fig. 1 : decrease by 35 %, p < 0.0001 by Anova and Dunnett’s test; decrease by 17 %, p < 0.027 by two-tailed t-test) that may attenuate α-secretase activity.

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