Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice.

Only the 3.5mg/kg diet produced a highly significant increase in lifespan, as judged by either the Mantel–Cox log-rank test ( p = .008) or the Gehan–Breslow–Wilcoxon test ( p = .009).

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The differences between the weights of the control and the 1.5 and 3.5g/kg diet-treated groups were close to significance by this test ( Table 1 ).

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