Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes.

However, a highly significant difference ( P = 9.4 × 10 -8 ) was observed between the K S distribution of ortholog pairs containing human disease genes, and the K S distribution of pairs not containing disease genes (Figure 1b ).

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Only a marginally significant difference was found between these two distributions using a Kolmogorov-Smirnov test ( P = 0.035) (Figure 1a ).

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