Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting.

In contrast to other granules, degranulation of azurophil granules seems unchanged by LPS suggesting that either (i) this granule type may require further cell activation to induce its mobilization towards the plasma membrane [ 43 ] or (ii) the upregulation of CD63 at the plasma membrane might not be significant enough to detect since azurophil granules are rather poor in receptors in contrast to secretory vesicles [ 35 ].

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