FAME 2: Reshaping the approach to patients with stable coronary artery disease.

Patient recruitment was stopped prematurely after randomizing 888 patients (originally targeting 1623) at the request of an independent data and safety monitoring board as a result of a highly significant difference in the incidence rates of the composite primary end-point between both groups. 6 The study's design in detail, as well as early results, have previously been discussed in the Journal. 7 The investigators published 2-year follow-up results late last year in the New England Journal of Medicine ( Figure 1 ). 8 Results and discussion At two years, the rate of the primary end point was significantly lower in the PCI group compared to the OMT group (8.1% vs. 19.5%, hazard ratio with PCI = 0.39; 95% CI = 0.26 – 0.57; p < 0.001).

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