(A caveat to this finding is that different antibody clones were used for the surface fluorescence-activated cell sorting (FACS) staining at baseline and at week 48 and, due to the possibility of different affinities, this is a possible confounder which needs to be explored in future studies.) The highly significant impact of the markers PD-1, Tim-3 and Lag-3 is intriguing, especially in view of the lack of association for markers of activation (HLA-DR, CD38), which might be expected to associate with rebound.
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Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.
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