The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Indeed, comparison of differentially included cassette exons in genes expressed in both neurons and ECs (see Supplementary Methods ) revealed a highly significant overlap between alternative exons predicted to be regulated by Nova proteins in the brain 33 and those showing changes in inclusion levels upon Nova2 knockdown in the endothelium ( P =1.93 e −11 , hypergeometric test; Supplementary Fig. 6 ; Supplementary Table 3 ), despite the very different approaches used in the two studies (see Supplementary Materials for details).

also in 132,142 other papers