A census of α-helical membrane proteins in double-stranded DNA viruses infecting bacteria and archaea.

TM content and topology in viral and microbial proteins The distributions of membrane proteins by the number of TM segments in representative sets of prokaryotic and viral genomes show striking, highly significant differences ( p -value < 1e-300 by Chi-Squared test and <2e-16 by Mann-Whitney-Wilcoxon test) whereas the archaeal and bacterial distributions are indistinguishable (Fig. 3 ).

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