The Cytoprotective Effects of E-α-(4-Methoxyphenyl)-2',3,4,4'-Tetramethoxychalcone (E-α-p-OMe-C6H4-TMC)--A Novel and Non-Cytotoxic HO-1 Inducer.

Among the 14 α-X-TMCs, E -α- p -OMe-C 6 H 4 -TMC displayed the most promising potential as a new therapeutic agent, demonstrating a highly significant reduction of annexin-V positive cells.

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α-Cl-TMC administration revealed a tendency to a reduced number of annexin-V positive cells, but failed to reach significance as was found for chalcone (see Figs 1 and 2 ).

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