Starting at 9 months of age, Pkd1 RC/RC mice develop a decline in renal function as measured by blood urea nitrogen levels and have a highly significant increase in cystic and fibrotic burden as measured by histomorphometric parameters, as well as TKV represented by percent kidney weight/body weight (KW/BW) ratio 20 , 23 .
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Utilizing magnetization transfer imaging to investigate tissue remodeling in a murine model of autosomal dominant polycystic kidney disease.
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