Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study.

Nutr Metab (Lond) · 2015 · PMC4647664 · PMID 26579206

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0.0080

closest p · 0.2× alpha

0.0080

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The sentences

borderline significanceP = 0.008actually significant

The correlation between dietary fat percentage and GGT levels in RC/CC premenopausal women showed borderline significance ( P = 0.008) and was also tested for interactions.

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marginal significanceno p-value reported

Although the ABCA1/ R230C diet interactions affecting HOMA-IR observed here had marginal significance ( P interaction = 0.058 and 0.075 for dietary fat and carbohydrate intake respectively), our data suggest that gender and diet are factors that added to ABCA1 function participate in the complex process of insulin resistance, and deserve further study.

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