Dopamine Regulates Approach-Avoidance in Human Sensation-Seeking.

Independent-samples median tests revealed that individuals who assigned a positive value to the opportunity to receive the MES (ie, θ>0, n =17) smoked significantly more cigarettes per week (Fisher’s P =.006) and showed a nonsignificant trend towards consuming more alcoholic drinks per week ( P =.098) than individuals who tended to avoid the MES (ie, θ<0, n=28) (mean cigarettes per week 6.7±10.4 vs 2.5±9.9; mean drinks per week 4.2±3.9 vs 3.4±4.9).

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Importantly, there was a highly significant relationship between preference for the intense sensory stimulus and choice RTs, consistent with the notion that the MES had motivational significance to participants.

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