Selective costimulation by IL-15R/IL-15, but not IL-2R/IL-2, allows the induction of high numbers of tumor-specific CD8+ T cells by human dendritic cells matured in conditions of acute inflammation

J Immunother Cancer · 2015 · PMC4649331

Europe PMC DOI

hedged sentence

0.0090

closest p · 0.2× alpha

0.0090

boldest claim

The sentences

highly significantp = 0.009actually significant

In accordance with the in vivo advantage of utilizing an IL-2-independent pathway of costimulation of tumor-specific T cells, in a retrospectively analyzed cohort of patients with metastatic malignant melanoma treated with cyclophosphamide and tumor-antigen transfected DCs ( NCT00978913 ) we observed a highly significant inverse relation between overall survival and expression of IL-2Rα on DC vaccine products (p = 0.009).

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