Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.

CPT as free drug and formulated in PEG NPs significantly inhibited the growth of these rapidly growing, aggressive murine tumors by ~30% on day 17; unPEGylated CPT NPs also inhibited tumor growth; however, this failed to reach significance ( Figure 2a and Supplementary Figure S3a ).

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