Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey.

Whilst our data are based on observational findings in a relatively small number of samples, and take no account of possible partial- or non-adherence to medication, the higher clozapine concentrations and the higher clozapine:norclozapine ratio may be significant factors determining the increased incidence of weight gain and dysmetabolic profiles in females prescribed clozapine.

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