In both cell lines we observed highly significant co-localization of pexMAVS CR with peroxisomes and mitoMAVS CR with mitochondria, while wtMAVS CR mainly localized to mitochondria, with a small proportion localizing to peroxisomes, consistent with the subcellular distribution of endogenous MAVS (cf.
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Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.
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