Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese.

Of the 5 highly significant single nucleotide polymorphisms (SNPs) on 1q32.1 that map to NR5A2 , rs3790844 showed the strongest association with pancreatic cancer, with a per-allele OR of 0.77 (95% CI: 0.71–0.84). rs3790843 was highly correlated with rs3790844 in the Pancreatic Cancer Consortium (PanScan) European controls (r 2 = 0.59) 8 .

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The incidence and mortality have shown an increasing trend over the past decades 1 .

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