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Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

PLoS One · 2015 · PMC4658150 · PMID 26599757

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an increasing trendno p-value reported
The drug resistance criteria include no significant decline in β-HCG after 2 therapeutic courses (not exceeding 1/10), stable β-HCG levels or an increasing trend in β-HCG levels.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.