First, a lot of the target sites reported by the CLIP-seq methods in the CDS region may be due to transient protein-binding events and, thus, the level of downregulation due to such binding sites may not be significant [ 18 , 54 , 55 ].
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First, a lot of the target sites reported by the CLIP-seq methods in the CDS region may be due to transient protein-binding events and, thus, the level of downregulation due to such binding sites may not be significant [ 18 , 54 , 55 ].