highly significantP <0.001
3c and Supplementary Data 5 ) relative to Wilms tumours, analysis using GSEA and the Database for Annotation, Visualization and Integrated Discovery (DAVID) 27 , 28 toolset also revealed a highly significant enrichment for homeobox proteins (FWER P <0.001; Supplementary Fig. 7 ) and upregulation of distinct classes of homeobox proteins, which are the canonical targets of polycomb-mediated repression.