SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril)-Induced Cough: a Pharmacogenetic Study.

Sci Rep · 2015 · PMC4660479 · PMID 26607661

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hedged sentences

0.0650

closest p · 1.3× alpha

0.0780

boldest claim

The sentences

marginal significanceP = 0.065so close (0.05 < p ≤ 0.1)

For the SLCO1B1 521T > C genotypes, in male patients, the risk of enalapril-induced cough in SLCO1B1 521C allele carriers was higher compared with TT genotype carriers, with marginal significance (OR = 2.06, 95%CI = 0.92–4.62 , P = 0.065), while female patients were still strongly associated with SLCO1B1 521T > C genotypes distribution (OR = 2.04, 95%CI = 1.16–3.60, P = 0.012).

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marginally significantP = 0.078so close (0.05 < p ≤ 0.1)

Additionally, the female subjects with the *15 haplotype (*1b/*15, *1a/*15, *15/*15) had a significantly increased risk for enalapril-induced cough, compared to other haplotypes (*1a/*1b, *1a/*1a, *1b/*1b) (OR = 2.00, 95%CI = 1.14–3.53, P = 0.016), while the findings in male patients were marginally significant (OR = 2.04, 95%CI = 0.92–4.56, P = 0.078).

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