Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites.

We calculated GRO-seq read counts near active and inactive CEBPB-bound sites based on the CRE-seq data and observed a highly significant enrichment in GRO-seq signal at active sites compared to inactive binding events ( P = 5.65 × 10 −5 ) (Supplemental Fig. 7).

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