Expression of B cell-specific Moloney murine leukemia virus integration site 1 in vulvar squamous cell carcinoma and its effect on the biological behavior of A-431 cells.

Oncol Lett · 2015 · PMC4665225 · PMID 26788137

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may be significantno p-value reported

In conclusion, BMI-1 expression is altered in VIN and VSCC and this may be significant for proliferation, apoptosis and invasion. siRNA targeting of BMI-1 successfully silenced BMI-1 expression in A-431 cells, and silencing BMI-1 significantly promoted apoptosis and inhibited the invasive and metastatic abilities of A-431 cells in vitro .

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an increasing trendno p-value reported

The expression rate of BMI-1 in normal vulvar, VIN and VSCC tissues was 0.0, 25.0 and 68.0% respectively, demonstrating an increasing trend in the severity of the disease.

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