Serum-derived bovine immunoglobulin/protein isolate in the alleviation of chemotherapy-induced mucositis.

At 6 h post-irinotecan treatment, there was a highly significant increase in neutrophils (as % of total WCC) in irinotecan groups (Fig. 3b ; P < 0.0001); however, this increase was less pronounced in groups administered SBI (non-significant; Fig. 3b ).

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While irinotecan-treated animals gavaged with 500 mg/kg SBI lost less weight than other groups, this failed to reach significance ( P = 0.10; Fig. 1a, b ).

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