Relationships between Chromosome 7 Gain, MET Gene Copy Number Increase and MET Protein Overexpression in Chinese Papillary Renal Cell Carcinoma Patients.

A highly significant correlation was observed between the percentage of tumor cells with MET gene copy number ≥3 and CEP7 copy number ≥3 (R 2 = 0.90, p <0.001) across two subtypes of PRCC.

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Furthermore, we also found an increasing trend in the percentage of tumor cells with MET gene copy number ≥3 together with higher MET IHC score, suggestive of a relationship between MET gene copy number increase and MET protein overexpression.

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Relationships between MET gene copy number increase and MET protein overexpression A positive trend was observed between % MET and increasing IHC score ( Fig 3 ), indicating a possible correlation between MET gene copy number increase and protein overexpression in PRCC tumor cells.

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