Fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity.

Aliment Pharmacol Ther · 2014 · PMC4670472 · PMID 24612278

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highly significantno p-value reported

Fatigue's association with all scores remained highly significant despite controlling for disease activity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.