DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.

In the absence of DDR inhibitors, PGE 2 levels increased several fold 24 or 48 h after 10 Gy γ-rays with most cell lines, with statistically significant differences in MCF7 and BJ1hTERT, and trending toward significance in HT1080 ( p = 0.06); HCT116 showed an approximately eightfold increase at 48 h, but significance could not be calculated because only a single determination was made at this time point (Figure 2 A).

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