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Adverse Events Associated with Fosfomycin Use: Review of the Literature and Analyses of the FDA Adverse Event Reporting System Database.

Infect Dis Ther · 2015 · PMC4675770 · PMID 26437630

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may be significantno p-value reported
Considering that an average dose of fosfomycin is about 12 g, the sodium load associated with its use may be significant, especially for patients with underlying heart failure.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.