The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis.

Sci Rep · 2015 · PMC4677309 · PMID 26658360

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highly significantno p-value reported

We found that co-culture of 3T3 and RAW macrophages alone (without TGFβ and M1 cytokines LPS and IFNγ) did not induce nitric oxide release (data not shown), but treatment with TGFβ (3T3 activation) and LPS/IFNγ (M1-differentiation) led to highly significant increase in NO release as compared to M1 macrophages mono-culture suggesting activated fibroblasts stimulates M1 activation.

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