marginally significantP <10 −5
Loci harboring marginally significant evidence for association at P <10 −5 were examined for independent signals via regression analyses in PLINK. 16 A term was added to the regression model including the lead SNP as a covariate, and SNPs within the same candidate gene, or ±200 kb if the candidate gene region was <200 kb, were evaluated for maintaining array-wide significance.