Detection and investigation of temporal clusters of congenital anomaly in Europe: seven years of experience of the EUROCAT surveillance system.

Eur J Epidemiol · 2015 · PMC4684832 · PMID 25840712

Europe PMC DOI

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an increasing trendno p-value reported

Two of the 44 new confirmed clusters occurred against a background of a significant decreasing trend, and two occurred in association with an increasing trend and may have been a manifestation of that trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.