highly significantp < 0.0001
Strikingly, for both protocols involving the injection of microbubbles, the peak amplitude displayed a highly significant increase, leading to 12 ± 2% (p < 0.0001) increase in PA for the thinned-skull and 9 ± 2% (p < 0.0001) PA increase in the transcranial configuration, as compared to the control imaging protocol (unpaired Student's t -test).