Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.

J Cell Biol · 2015 · PMC4687875 · PMID 26694839

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highly significantno p-value reported

This quantitative and highly significant correlation ( r = −0.86) was documented with multiple γ inhibitors, including some used in AD clinical trials: Begacestat, Avagacestat, and Semagacestat.

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