Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor.

The neovascular development, in response to the tumor hypoxia, follows an oscillatory pattern with an increasing trend in time, reaching 0.5 by Day 17, whereas the pre-existing vasculature-to-tumor ratio remains fairly constant at ~0.1 after Day 6 as the growing tumor begins to co-opt the surrounding vessels.

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