TERT promoter mutations and monoallelic activation of TERT in cancer.

Among cell lines with monoallelic TERT expression, we found a highly significant difference in the distribution across lineages when compared with cell lines with biallelic expression of TERT for both promoter-mutant and promoter-wild-type cell lines ( P =1.59 × 10 −6 and P =0.006, respectively; Fisher–Freeman–Halton test; Figure 2 ).

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