Infection-related hospitalizations over 30 years of follow-up in patients starting renal replacement therapy at pediatric age.

It is of major concern that recent reports show an increasing trend in infection-related mortality, both in dialysis and transplanted patients, and not only in incident patients, but also in patients with a long history of RRT, years after transplantation [ 15 , 16 ], with an infectious mortality rate increasing from 0.51/100 patient-years (py) before 1989 to 0.82/100 py after 2000 in a Dutch cohort [ 17 ].

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The persisting burden of PD-related peritonitis contrasts with data from two European centers, an Australian center and a Canadian Registry, all showing a decreasing trend over time [ 44 – 47 ].

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