Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.

Int J Mol Sci · 2015 · PMC4691135 · PMID 26690424

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hedged sentences

0.0500

closest p · 1.0× alpha

0.0580

boldest claim

The sentences

did not quite attain significancep < 0.05actually significant

Although odds ratios associated with the CC genotype were between 1.77 and 2.26 indicating an approximately doubled risk of breast cancer, these observations did not quite attain significance at the p < 0.05 level, which may be due to the small number of CC patients ( Table 2 ).

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of borderline significancep = 0.058so close (0.05 < p ≤ 0.1)

Curves of the cumulative breast cancer incidence also showed a considerably earlier age at breast cancer onset of CC patients, which was of borderline significance ( p = 0.058, log-rank test; Figure 1 B). 3.

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borderline significanceno p-value reported

This increased the magnitude of the observed effects, and borderline significance was obtained for comparisons of the rare CC genotype with the other genotypes ( Table 2 ).

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almost reached statistical significanceno p-value reported

Thus, rs1346044 was significantly associated with an increased breast cancer risk in patients under 55 years based on recessive and log-additive genetic models and almost reached statistical significance based on a dominant model ( Table 3 ; see also next section results, below).

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